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‘Many people who tested negative for Coronavirus might actually have it,’ warn scientists

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As the countries worldwide are busy fighting the Coronavirus, and now have increased the tests for disease, scientists have warned about a growing concern: Many people with negative results might actually have the virus, leading to devastating implications.

Now most of the countries would need to open the lockdown imposed to stop the spread of virus as global recession looms and governments wrangle with the question of when to reopen economies. Billions of people are currently staying at home in an effort to break transmission of the deadly disease.

As the Coronavirus has only been spreading among humans for four months and therefore studies about test reliability are still considered preliminary. Around the world, most of the COVID-19 detection tests use a technology called PCR, which detects pieces of the coronavirus in mucus samples.

But “there are a lot of things that impact whether or not the test actually picks up the virus,” news ageny AFP quoted Priya Sampathkumar, an infectious diseases specialist at Mayo Clinic in Minnesota.

“It depends on how much virus the person is shedding (through sneezing, coughing and other bodily functions), how the test was collected and whether it was done appropriately by someone used to collecting these swabs, and then how long it sat in transport,” she said.

China reported that the ability of the tests to return positive results when the virus is present, is somewhere around 60 to 70 percent.

While companies involved in tests around the world are now producing slightly varying tests, so it’s hard to have a precise overall figure. But even if it were possible to increase the sensitivity ( meaning how well it is able to return positive results) to 90 percent, the magnitude of risk remains substantial as the number of people tested grows, Sampathkumar argued in a paper published in Mayo Clinic Proceedings.

“In California, estimates say the rate of COVID-19 infection may exceed 50 percent by mid-May 2020,” she added.

With 40 million people, “even if only one percent of the population was tested, 20,000 false-negative results would be expected.”

So it is critical that clinicians base their diagnosis on more than just the test and also should examine a patient’s symptoms, their potential exposure history, imaging and other lab work.

Part of the problem lies in locating the virus as its area of highest concentration shifts within the body.

The main nasal swab tests examine the nasopharynx, where the back of the nose meets the top of the throat. This requires a trained hand to perform and some portion of the false negatives arises from improper procedure.

As the virus passes from the upper to the lower respiratory system as the disease progresses. Therefore, the swab may produce a false negative, even if done correctly.

In these cases, doctors may need to take a sample more evasively, when a patient is under sedation. The patient may be asked to try to cough up sputum — mucus from the lower lungs.

Daniel Brenner, an emergency physician at Johns Hopkins Hospital in Baltimore, told AFP that taking a test after performing a procedure called a bronchoalveolar lavage was done on a patient whose nasal swab returned negative three times, but who showed all the signs of COVID-19.

Eventually, the patient’s medical team placed a camera down his windpipe to examine the lungs, then sprayed fluid in and sucked out the secretions, which were then tested, resulting in a positive.

Uncertainty in clinical diagnoses is not new, and clinicians are well aware that no type of test for any condition can be considered perfect.

What makes COVID-19 different is its newness, said Sampathkumar. “Most of the time when you have tests, you have test characteristics outlined carefully and warnings about tests interpretation,” she said.

“We had no test for so long, and when we got the test, we started using it widely and sort of forgot the basics.”

After being slow to start mass testing, the US has ramped up production and has tested almost 2.5 million people, with pharmacists now authorized to carry out the procedure.

But “the real fear of that is people who are given a false negative test and then decide that they’re safe to go around their daily life and go out and expose people,” said Brenner.

Much hope is placed on newly available serological tests which look for antibodies produced by a person’s body in response to the virus and can tell whether a person was infected, long after they recovered.

They could also be used to help diagnose a person who is currently infected but whose PCR test results showed a false negative, by waiting a week or so for the body to produce its immune response.

“We are excited about the serologic test, but we don’t know how well it will work and we are starting to study it,” said Sampathkumar.

(With inputs from AFP)

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Shraddha Murder Case: Police found spinal cord, 10 body parts recovered so far from the forest

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Photo by Hassan Rafhaan on Unsplash | (Representational Image)

The bones of Shraddha found by the Delhi Police in the forest of Mehrauli belong to the back part of the body. About 10 such body parts have been found so far, including the reed bone. Apart from this, some bones have also been recovered from the drain.

Delhi Police has received 10 parts of the body including the lower part of the spinal cord. The police have also found blood stains in the kitchen of the flat, whose samples have been sent for examination to find out whose the blood stains are.

Aftab had cleaned the fridge with chemicals so that when caught, he could spoil the forensic investigation. Delhi Police will soon call Shraddha’s father for a DNA sample. After which blood sample and bone sample will be sent to FLS, after which FSL will do a DNA test.

After the investigation so far, the police suspect that Shraddha’s body was dismembered in the bathroom after the murder. Along with this, the accused used to leave the water running from the shower so that the dead body could be easily cut and blood flowed. The FSL team along with Aftab was present during the investigation at his flat.

Source: Aajtak

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Fog will be seen in Delhi’s sky from tomorrow, cold will increase with drop in temperature!

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Representational Image | Image Source: Sumita Roy Dutta (Wikimedia)

After the passing of half of November, there is a rapid change in the weather. The country’s capital Delhi is feeling cold in the morning and evening, while the temperature is rising in the afternoon. However, a change in the weather can be seen in the coming days. According to IMD, the cold may increase in Delhi from tomorrow i.e. 17 November with a drop in temperature.

Delhi’s temperature condition

According to weather experts, in the next few days, icy winds will blow in the northwest direction, due to which Delhi’s temperature will drop and the cold will increase. Talking about the temperature, on November 17, the minimum temperature can be 12 degrees Celsius and the maximum temperature can be 27 degree Celsius. Two days ago i.e. on November 15, the minimum temperature was recorded at 15 degrees and the maximum temperature was 30 degrees. At the same time, there is a possibility of further decline in it for the next two days. On November 18, the minimum temperature can reach 11 °C and the maximum temperature can reach 26 °C.

Source Aajkal.in

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In Delhi, 37 lakh people apply for power subsidy

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Representational Image | Image Source: Snappygoat.com

After the 15-day-expansion by the Delhi government to select for the power subsidy scheme finished Tuesday, just three lakh individuals applied during the augmentation time frame. From September 14 till Tuesday night, 37,13,179 individuals applied to keep on benefiting from the subsidy scheme.

In spite of the fact that authorities are guaranteeing that a decent level of individuals has applied, the information shows a distinction of around 10 lakh customers when contrasted with a year ago. As per the information, around 46.8 lakh individuals profited from the advantage under the plan in 2021-22.

“This was the normal number of individuals who get the advantage, and the people who go under the 200 unit class probably applied. Likewise, the number varies as a few purchasers get the financed bill during winters and the number descends in summer as individuals use ACs, coolers, and fans,” said a senior authority from the power office.

He added that individuals who got sponsored bills under 400 units during winter should not have applied. “In any case, they can, in any case, apply before their next charging cycle and profit from the subsidy scheme,” said the official.

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